Brewers vs Cubs: NLDS Game 5 Preview & Betting Guide

On a Friday, October 10, the Milwaukee Brewers (season record 62-38) take on the Chicago Cubs (season record 58-42) in the final Game 5 of the National League Division Series (NLDS) at American Family Field in Milwaukee. The Brewers have their star to the mound, and the Cubs do the same, and the playoffs will become a battle of wit and woo. Pitching duels, tactical battles and offensive possible fireworks will be expected as both teams battle to make the NLCS. Get professional analysis of the pitchings, the center hitters, and betting angles of this game.

Match Overview

Detail	Information
Date	Friday, 10 October 2025
Time	8:08 PM ET
Venue	American Family Field, Milwaukee, WI
Teams	Chicago Cubs vs. Milwaukee Brewers
League	Major League Baseball (MLB)

The Chicago Cubs will travel to Milwaukee to face the Brewers on Friday, October 10, 2025. First pitch is at 8:08 PM ET. The Brewers are favorites with a moneyline of 1.71 (-141), while the Cubs are underdogs at 2.18 (+118). The over/under is set at 7.5 runs, with Milwaukee favored on the run line (-1.5, 2.59).

Game Odds & Lines

Bet Type	Odds
Moneyline	Chicago: 2.18 • Milwaukee: 1.71
Run Line	Chicago +1.5: 1.94 • Milwaukee -1.5: 2.59
Total Runs (O/U)	Over 7.5: 1.95 • Under 7.5: 1.85

Starting Pitchers

Team	Starting Pitcher
Chicago Cubs	TBD (Season ERA: 2.45, W-L: 7-3)
Milwaukee Brewers	TBD (Season ERA: 3.17, W-L: 4-6)

Weather & Ballpark Conditions

Forecast: Clear skies, 64°F
Wind: Light wind blowing in from left field at 6 mph
Humidity: 55%
Ballpark Factor: Neutral, slight edge to hitters

Last 5 Games Record

Team	Last 5 Games
Chicago Cubs	W, L, W, W, L
Milwaukee Brewers	W, L, L, W, W

Head-to-Head Record

Stat	Value
2025 Season Series	Brewers 2 – 2 Cubs
Last 10 Meetings	Evenly split 5-5

Key Insights & Betting Trends

• Brewers have performed well at home, winning 37 of 49 games as favorites this season.
• Cubs have struggled as underdogs in away playoff games, winning just 19 of 49 contests.
• Brewers’ offense has been consistent with Christian Yelich and Brice Turang leading the charge.
• Cubs rely on Kyle Tucker and Nico Hoerner for key offensive production.
• Milwaukee has a slight edge in pitching depth and bullpen reliability.

Expert Picks & Recommended Bets

• Moneyline: Brewers @ 1.71
• Run Line: Brewers -1.5 @ 2.59
• Total Runs: Over 7.5 @ 1.95

Chicago Cubs vs. Milwaukee Brewers Predicted Outcome

The Brewers’ home-field advantage and strong pitching depth give them the upper hand in this elimination game. While the Cubs have offensive talent, Milwaukee’s combination of veteran starters and timely hitting should secure the win. Expect a close, competitive game that leans slightly over the total runs. Final predicted score: Brewers 5, Cubs 4.

Sources: https://www.oddsshark.com/, https://www.cbssports.com/, https://www.foxsports.com/, https://www.mybookie.ag/sportsbook/