Cubs vs Brewers Game 5 Preview: Who Advances to NLCS?

On Friday, October 10, 2025, the Chicago Cubs (92–70) host the Milwaukee Brewers (97–65) at Wrigley Field in Game 4 of the National League Division Series (NLDS). The series is tied 2–2, making this a crucial matchup for both teams. The Cubs aim to advance to the NL Championship Series, while the Brewers look to clinch the series and move forward.

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Match Overview

Detail	Information
Date	Friday, 10 October 2025
Time	9:08 PM ET
Venue	Wrigley Field, Chicago, IL
Teams	Chicago Cubs vs. Milwaukee Brewers
League	Major League Baseball (MLB)

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The Chicago Cubs will face the Milwaukee Brewers at Wrigley Field on Friday, October 10, 2025. The first pitch is scheduled for 9:08 PM ET. The Cubs are coming off a dominant 6–0 victory in Game 4, forcing a decisive Game 5. With the series tied 2–2, this game will determine which team advances to the NL Championship Series.

ALSO READ: Detroit Tigers vs. Seattle Mariners ALDS Game 5: Odds, Prediction & Expert Picks

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Game Odds & Lines

Bet Type	Odds
Moneyline	Milwaukee: 1.81
	Chicago: 2.10
Run Line	Milwaukee -1.5: 2.10
	Chicago +1.5: 1.80
Total Runs (O/U)	Over 7.5: 1.90
	Under 7.5: 1.90

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Starting Pitchers

Team	Starting Pitcher
Chicago Cubs	Matthew Boyd (14–9, 3.18 ERA)
Milwaukee Brewers	Freddy Peralta (18–7, 2.80 ERA)

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Weather & Ballpark Conditions

• Forecast: Clear skies, 68°F (20°C)
• Wind: Blowing in from center at 7 mph
• Humidity: 54%
• Ballpark Factor: Slight edge to pitchers due to wind direction

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Last 5 Games Record

Team	Last 5 Games
Chicago Cubs	W, W, L, L, W
Milwaukee Brewers	L, L, W, W, L

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Head-to-Head Record

Stat	Value
2024 Season Series	Cubs 3 – 4 Brewers
Last 10 Meetings	Brewers lead 6–4

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Key Insights & Betting Trends

• The Cubs have won three of their last five games.
• The Brewers have struggled in their recent away games.
• Boyd has shown resilience in high-pressure situations.
• Peralta has been dominant on the road this season.
• The Cubs’ bullpen has been effective in late-game situations.

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Expert Picks & Recommended Bets

• Moneyline: Cubs at 2.10
• Run Line: Cubs +1.5 at 1.80
• Total Runs: Under 7.5 at 1.90

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Chicago Cubs vs. Milwaukee Brewers Predicted Outcome

Matthew Boyd delivered a stellar performance in Game 4, pitching 4⅔ scoreless innings while striking out six and allowing only two hits. Ian Happ jumpstarted the Cubs’ offense with a three-run homer in the first inning, and the Cubs kept pressure on the Brewers’ bullpen throughout. With Boyd’s momentum and the home-field advantage, the Cubs are poised to secure a 5–3 victory, advancing to the NL Championship Series.

Sources: https://www.oddsshark.com/, https://www.cbssports.com/, https://www.foxsports.com/, https://www.mybookie.ag/sportsbook/