New York Yankees vs. San Diego Padres Match Prediction and MLB Tips – May 8, 2025

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On Thursday, May 8, the Padres (17-18) travel to the Bronx to face the Yankees (22-13) in an interleague game at Yankee Stadium. San Diego sends right-hander Joe Musgrove to the mound, while New York answers with lefty Carlos Rodón. As the Padres try to go back to.500 and the Yankees try to maintain their great home record, this game has fascinating stories on both sides. Get expert insight on pitching matchups, core hitters, and strategy angles for this game.

Match Overview

DateTime (ET)VenueTeamsLeague
Thursday, 8 May 20256:45 PM ETYankee Stadium, New York, NYSan Diego Padres @ New York YankeesMajor League Baseball (MLB)

On Thursday, May 8, 2025, the San Diego Padres will take on the New York Yankees at Yankee Stadium in New York. The first pitch is scheduled at 6:45 PM ET. The Yankees are the favourites with a moneyline of 1.62, while the Padres are the underdogs at 2.35. New York is the run line favourite (-1.5, 2.05), while the over/under for the game is set at 8.5 runs.

Check out our other prediction for the Tampa Bay Rays vs. Philadelphia Phillies game!


Game Odds & Lines

Bet TypeOdds
MoneylinePadres: 2.35 • Yankees: 1.62
Run LinePadres +1.5: 1.80 • Yankees -1.5: 2.05
Total Runs (O/U)Over 8.5: 1.90 • Under 8.5: 1.90

Starting Pitchers

TeamStarting Pitcher
PadresJoe Musgrove (2-3, 4.91 ERA)
YankeesCarlos Rodón (4-1, 3.67 ERA)

Weather & Ballpark Conditions

  • Forecast: Partly cloudy, 66°F
  • Wind: Blowing in from right field at 7 mph
  • Humidity: 63%
  • Ballpark Factor: Slight edge to pitchers based on today’s conditions

Last 5 Games

TeamRecord (Last 5 Games)
Padres3-2 (W-L-W-W-L)
Yankees4-1 (W-W-L-W-W)

Head-to-Head Record

Matchups (Last 5 Meetings)Result
Yankees vs PadresYankees lead 3-2

Key Insights & Betting Trends

  • The Yankees have won four of their last five games.
  • The Padres have averaged 2.3 home runs per game during their previous three games.
  • Rodón has a 3.67 ERA after six starts.
  • The Padres’ road record this season is 7-12.
  • The Yankees are up to bat. 268 in the home

Check out our other prediction for the Los Angeles Dodgers vs. Miami Marlins game!


Expert Picks & Recommended Bets

  • Moneyline: Yankees @ 1.62
  • Run Line: Yankees -1.5 @ 2.05
  • Total Runs: Under 8.5 @ 1.90

New York Yankees vs. San Diego Padres Predicted Outcome

The Yankees come in with stronger recent form and a more consistent starter in Carlos Rodón, who has looked sharp at home. While Musgrove has struggled with command and ERA this season, the Yankees’ offense should be able to apply pressure early. Expect a low-to-mid scoring game with the Yankees taking a narrow win.

Check out our other prediction for the Toronto Blue Jays vs. Los Angeles Angels game!

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