Philadelphia Phillies vs. Cleveland Guardians Match Prediction and MLB Tips – May 10, 2025

Table of Contents

On Saturday, May 10, the Phillies (16-19) go to Cleveland to play the Guardians (15-20) in a crucial interleague game. Philadelphia will send ace Aaron Nola to the mound, while Cleveland will reply with Gavin Williams. Both sides are looking to bounce back from recent disappointments and raise their standings. Get expert insight on pitching matchups, core hitters, and strategy angles for this game.

Match Overview

DateTime (ET)VenueTeamsLeague
Saturday, 10 May 20257:10 PMProgressive Field, Cleveland, OHPhiladelphia Phillies @ Cleveland GuardiansMLB

Intro Content

On Saturday, May 10, 2025, the Philadelphia Phillies will take on the Cleveland Guardians at Progressive Field in Cleveland. At 7:10 p.m. ET, the first pitch will be made. The Phillies are the favourites with a moneyline of 1.80, while the Guardians are the underdogs at 2.05. The over/under for the game is eight runs, and Philadelphia is the favourite on the run line (-1.5, 2.40).

Check out our other prediction for the Cincinnati Reds vs. Houston Astros game!


Game Odds & Lines

Bet TypeOdds
MoneylinePhillies: 1.80 • Guardians: 2.05
Run LinePhillies -1.5: 2.40 • Guardians +1.5: 1.61
Total Runs (O/U)Over 8: 1.91 • Under 8: 1.91

Starting Pitchers

TeamPitcherRecord (W-L)ERA
GuardiansGavin Williams2-25.06
PhilliesAaron Nola1-54.61

Weather & Ballpark Conditions

ForecastWindHumidityBallpark Factor
Mostly clear, 67°FBlowing out to left at 5 mph60%Slight edge to hitters

Last 5 Games Record

TeamRecord (W-L)Notes
Guardians2-3Recent struggles at home
Phillies3-2Improved performance on the road

Head-to-Head Record

Last 5 MeetingsRecord (W-L)Notes
Guardians2-3Close contests historically
Phillies3-2Slight edge in recent matchups

Key Insights & Betting Trends

  • Guardians have covered the run line in 62% of the simulations,
  • Simulations show that the Phillies have a 51% chance of winning.
  • The probability of less than eight runs is 53%.
  • The Guardians have not played well at home lately.
  • Lately, the Phillies’ offence has been more reliable.

Check out our other prediction for the Toronto Blue Jays vs. Seattle Mariners game!


Expert Picks & Recommended Bets

  • Moneyline: Guardians @ 2.05
  • Run Line: Guardians +1.5 @ 1.61
  • Total Runs: Under 8 @ 1.91

Philadelphia Phillies vs. Cleveland Guardians Predicted Outcome

Even though the Phillies are the slight favourites, Cleveland is a desirable pick because of the value on the moneyline, the Guardians’ ability to cover the run line, and the game’s propensity to stay under eight runs. Pitching will be a key factor in this hotly contested game.

Check out our other prediction for the Chicago Cubs vs. New York Mets game!

Sources: https://baseball.realgm.com/, https://www.betus.com.pa/sportsbook/mlb/, https://sportsbook.fanduel.com/navigation/mlb, https://www.statsinsider.com.au/

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