Chicago Cubs vs. San Francisco Giants game Prediction and MLB Sportsbook Tips – May 6, 2025

This article analyzes important variables that might affect the result of the Chicago Cubs vs. San Francisco Giants game that is scheduled for Tuesday, May 6, at Wrigley Field. It will predict the anticipated result of the game by analyzing team performance, current trends, and the contributions of important players.

Match Overview

DateTime (ET)VenueTeamsLeague
Tuesday, 6 May 20257:40 PMWrigley Field, Chicago, ILSan Francisco Giants @ Chicago CubsMLB

The San Francisco Giants will play the Chicago Cubs at Wrigley Field in Chicago on Tuesday, May 6, 2025. The first pitch is set for 7:40 p.m. ET. With a moneyline of 1.68, the Cubs are the favourites, and the Giants are the underdogs (2.24). The game’s over/under is set at 7.5 runs, and Chicago is the run line favourite (-1.5, 2.50).

Check out our other prediction for the St. Louis Cardinals vs. Pittsburgh Pirates game!


Chicago Cubs vs. San Francisco Giants Game Odds & Lines

Bet TypeOdds
MoneylineSan Francisco Giants: 2.24 • Chicago Cubs: 1.68
Run LineGiants +1.5: 1.55 • Cubs -1.5: 2.50
Total Runs (O/U)Over 7.5: 1.91 • Under 7.5: 1.91

Starting Pitchers

TeamPitcher
San Francisco GiantsLanden Roupp (2-2, 5.10 ERA)
Chicago CubsMatthew Boyd (2-2, 2.70 ERA)

Weather & Ballpark Conditions

  • Forecast: Mostly clear, 67°F
  • Wind: Blowing out to left at 5 mph
  • Humidity: 60%
  • Ballpark Factor: Slight edge to hitters based on today’s conditions

Key Insights & Betting Trends

  • The Cubs are 57% likely to win.
  • The Giants cover the +1.5 line 63% of the time.
  • 55% of simulations have hits of less than 7.5 runs.
  • Roupp’s ERA is 5.10, whereas Boyd’s is 2.70.
  • The Giants provide value at odds of 2.24.

Expert Picks & Recommended Bets

  • Moneyline: San Francisco Giants @ 2.24
  • Run Line: Giants +1.5 @ 1.55
  • Total Runs: Under 7.5 @ 1.91

Chicago Cubs vs. San Francisco Giants Predicted Outcome

Despite the Cubs’ slight advantage (57% win probability), the Giants are a desirable pick due to their favourable odds and 63% simulation coverage of the +1.5 run line. In addition, considering the pitching matchup and weather, the under on total runs is a compelling factor.

Sources: https://baseball.realgm.com/, https://www.betus.com.pa/sportsbook/mlb/, https://sportsbook.fanduel.com/navigation/mlb, https://www.statsinsider.com.au/

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