St. Louis Cardinals vs. Pittsburgh Pirates Prediction and MLB Sportsbook Tips – May 6, 2025

This article analyzes important variables that might affect the result of the St. Louis Cardinals vs. Pittsburgh Pirates game that is scheduled for Tuesday, May 6, at Busch Stadium. It will predict the anticipated result of the game by analyzing team performance, current trends, and the contributions of important players.

Match Overview

DateTime (ET)VenueTeamsLeague
Tuesday, 6 May 20257:45 PMBusch Stadium, St. Louis, MOPittsburgh Pirates @ St. Louis CardinalsMajor League Baseball (MLB)

The Pittsburgh Pirates will play the St. Louis Cardinals at Busch Stadium in St. Louis on Tuesday, May 6, 2025. The first pitch is set for 7:45 p.m. ET. With a moneyline of 1.64, the Cardinals are the favourites, and the Pirates are the underdogs at 2.33. The game’s over/under is set at 8.5 runs, and St. Louis is the run line favourite (-1.5, 2.38).

Check out our other prediction for the Chicago Cubs vs. San Francisco Giants game!


St. Louis Cardinals vs. Pittsburgh Pirates Game Odds & Lines

Bet TypeOdds
MoneylinePirates: 2.33 • Cardinals: 1.64
Run LinePirates +1.5: 1.61 • Cardinals -1.5: 2.38
Total Runs (O/U)Over 8.5: 1.91 • Under 8.5: 1.91

Starting Pitchers

TeamPitcher
Pittsburgh PiratesCarmen Mlodzinski (1-3, 6.58 ERA)
St. Louis CardinalsMiles Mikolas (1-2, 4.66 ERA)

Weather & Ballpark Conditions

  • Forecast: Mostly clear, 67°F
  • Wind: Blowing out to left at 5 mph
  • Humidity: 55%
  • Ballpark Factor: Slight edge to hitters based on today’s conditions

Key Insights & Betting Trends

  • The Cardinals have a 57% chance of winning.
  • Pirates are predicted to cover 62% of the +1.5 line.
  • 55% of simulations were predicted to run under 8.5 runs.
  • Pirates provides a 2% moneyline betting advantage.
  • Mikolas’s ERA was lower than Mlodzinski’s.

Expert Picks & Recommended Bets

  • Moneyline: Pittsburgh at 2.33
  • Run Line: Pirates +1.5 at 1.61
  • Total Runs: Under 8.5 at 1.91

St. Louis Cardinals vs. Pittsburgh Pirates Predicted Outcome

The Pirates provide value despite the Cardinals being the favourite, with a 2% betting lead. Mlodzinski has a better ERA, so expect a competitive game. Another important factor to take into account is the under on total runs.

Sources: https://baseball.realgm.com/, https://www.betus.com.pa/sportsbook/mlb/, https://sportsbook.fanduel.com/navigation/mlb, https://www.statsinsider.com.au/

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