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Brewers vs Cubs: NLDS Game 5 Preview & Betting Guide

Home | MLB | Brewers vs Cubs: NLDS Game 5 Preview & Betting Guide

On a Friday, October 10, the Milwaukee Brewers (season record 62-38) take on the Chicago Cubs (season record 58-42) in the final Game 5 of the National League Division Series (NLDS) at American Family Field in Milwaukee. The Brewers have their star to the mound, and the Cubs do the same, and the playoffs will become a battle of wit and woo. Pitching duels, tactical battles and offensive possible fireworks will be expected as both teams battle to make the NLCS. Get professional analysis of the pitchings, the center hitters, and betting angles of this game.

Match Overview

DetailInformation
DateFriday, 10 October 2025
Time8:08 PM ET
VenueAmerican Family Field, Milwaukee, WI
TeamsChicago Cubs vs. Milwaukee Brewers
LeagueMajor League Baseball (MLB)

The Chicago Cubs will travel to Milwaukee to face the Brewers on Friday, October 10, 2025. First pitch is at 8:08 PM ET. The Brewers are favorites with a moneyline of 1.71 (-141), while the Cubs are underdogs at 2.18 (+118). The over/under is set at 7.5 runs, with Milwaukee favored on the run line (-1.5, 2.59).

Game Odds & Lines

Bet TypeOdds
MoneylineChicago: 2.18 • Milwaukee: 1.71
Run LineChicago +1.5: 1.94 • Milwaukee -1.5: 2.59
Total Runs (O/U)Over 7.5: 1.95 • Under 7.5: 1.85

Starting Pitchers

TeamStarting Pitcher
Chicago CubsTBD (Season ERA: 2.45, W-L: 7-3)
Milwaukee BrewersTBD (Season ERA: 3.17, W-L: 4-6)

Weather & Ballpark Conditions

Forecast: Clear skies, 64°F
Wind: Light wind blowing in from left field at 6 mph
Humidity: 55%
Ballpark Factor: Neutral, slight edge to hitters

Last 5 Games Record

TeamLast 5 Games
Chicago CubsW, L, W, W, L
Milwaukee BrewersW, L, L, W, W

Head-to-Head Record

StatValue
2025 Season SeriesBrewers 2 – 2 Cubs
Last 10 MeetingsEvenly split 5-5
  • Brewers have performed well at home, winning 37 of 49 games as favorites this season.
  • Cubs have struggled as underdogs in away playoff games, winning just 19 of 49 contests.
  • Brewers’ offense has been consistent with Christian Yelich and Brice Turang leading the charge.
  • Cubs rely on Kyle Tucker and Nico Hoerner for key offensive production.
  • Milwaukee has a slight edge in pitching depth and bullpen reliability.
  • Moneyline: Brewers @ 1.71
  • Run Line: Brewers -1.5 @ 2.59
  • Total Runs: Over 7.5 @ 1.95

Chicago Cubs vs. Milwaukee Brewers Predicted Outcome

The Brewers’ home-field advantage and strong pitching depth give them the upper hand in this elimination game. While the Cubs have offensive talent, Milwaukee’s combination of veteran starters and timely hitting should secure the win. Expect a close, competitive game that leans slightly over the total runs. Final predicted score: Brewers 5, Cubs 4.

Sources: https://www.oddsshark.com/, https://www.cbssports.com/, https://www.foxsports.com/, https://www.mybookie.ag/sportsbook/

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