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Tampa Bay Rays vs. Baltimore Orioles One-on-One Prediction & Odds (Sept 23, 2025)

Home | MLB | Tampa Bay Rays vs. Baltimore Orioles One-on-One Prediction & Odds (Sept 23, 2025)

On Tuesday, September 23, the Tampa Bay Rays (76–80) travel to Camden Yards to take on the Baltimore Orioles (73–83) at 6:35 PM ET. The Rays send right-hander Ryan Pepiot to the mound, while the Orioles counter with righty Dean Kremer. Expect an evenly matched affair with some betting value in the total and possibly underdog upside.


Match Overview

DetailInformation
DateTuesday, September 23, 2025
Time6:35 PM ET
VenueOriole Park at Camden Yards, Baltimore, MD
TeamsTampa Bay Rays vs. Baltimore Orioles
LeagueMajor League Baseball (MLB)

The Rays visit the Orioles in Baltimore on Tuesday, September 23, 2025, with first pitch scheduled at 6:35 PM ET. Tampa Bay is a slight favourite, with moneyline around -120 for the Rays, while Baltimore is just behind. The run-line has Tampa Bay as −1.5 underdogs/favourites in various markets, and the over/under is in the 8.5-9.0 runs range.

ALSO READ: Scores and Odds Explained: A Beginner’s Guide to Sports Betting


Game Odds & Lines

Bet TypeOdds
MoneylineRays: approx -120 • Orioles: approx -100
Run LineRays −1.5: around +140 • Orioles +1.5: around −170
Total Runs (O/U)Over 8.5 or 9.0: slight juice • Under also playable in certain books

Starting Pitchers

TeamStarting PitcherSeason Stats & Notes
Tampa Bay RaysRyan PepiotRecord 11-11; ERA ~ 3.77; WHIP ~ 1.16. Strong strikeout numbers; opponents batting ~.220 vs him. Some concern over home run rate and recent outing where he struggled.
Baltimore OriolesDean KremerRecord 10-10; ERA ~ 4.39; WHIP ~ 1.24-1.26. Has had mixed recent results: some good starts, some where he’s given up multiple runs. Tends to allow more fly balls and is somewhat vulnerable to home runs.

Weather & Ballpark Conditions

  • Camden Yards is known to be somewhat friendly to hitters, especially in terms of home runs allowed.
  • No major weather issues indicated in the reports (no rain delays or extreme wind mentioned).
  • Night game temperatures and conditions could slightly favour the ball carrying.

Last 5 Games Record / Recent Form

TeamLast 5 Games
RaysMixed performance; some strong offensive outputs, though not consistently. They’ve been competitive but have also had trouble closing out games.
OriolesAlso struggling to put together long winning streaks; when underdogs, have had a few surprising results. Offensively inconsistent; bullpen and pitching have been up and down.

ALSO READ: Responsible Gambling 101: Safe Practices for New Bettors

Head-to-Head / Season Series

  • Dean Kremer has had some success against the Rays this season. In earlier matchups he’s pitched well; one earlier start vs Tampa Bay at home/road where he allowed very few runs.
  • The Rays have displayed better team ERA and batting average overall vs. AL teams, which gives them a slight edge.

  • The over (higher total runs) has been hit in many of Tampa Bay’s recent games when they are favourites versus AL East opponents.
  • Baltimore has struggled at home in many recent games, especially in close matchups.
  • Pepiot’s home run rate and control issues (walks) could make this game volatile.
  • Bullpens may factor late: Tampa Bay’s bullpen has generally been more reliable in recent weeks; Baltimore’s less so.

  • Moneyline: Lean Rays ML (−120 or thereabouts)
  • Run Line: Rays −1.5 possibly viable if they get off to a good start.
  • Total Runs: Over 8.5 or 9.0 seems likely; however, some analysts are taking the Under in certain sportsbooks given pitching matchup strength and if runs are hard to come by early.

Prediction & Expected Outcome

Dean Kremer’s past success vs Tampa Bay and Baltimore playing at home give them a chance, but Pepiot has been solid this season and the Rays have more reliable offensive weapons going into this. Expect a competitive game with some back-and-forth scoring. Final predicted score: Rays 5, Orioles 4, with a slight lean toward the over in total runs.

Sources: https://www.oddsshark.com/, https://www.cbssports.com/, https://www.foxsports.com/, https://www.mybookie.ag/sportsbook/

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